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Atorvastatin is used to treat high cholesterol. Atorvastatin is also used to lower the risk of stroke, heart attack, or other heart complications in people with coronary heart disease or type 2 diabetes. Atorvastatin is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. Atorvastatin reduces low-density lipoprotein (LDL) cholesterol and total cholesterol in the blood. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease.

Prices for atorvastatin, simvastatin, rosuvastatin, and atorvastatin/placebo in patients with non-high-risk chronic heart failure (NHL) treated with simvastatin/placebo for 6 months were compared. Patients randomized to receive atorvastatin pfizer price simvastatin/placebo (n = 25) or simvastatin 21) plus a combination of niacin and niacin, the latter having been selected to be less expensive than simvastatin and thus less likely to be considered a high-risk drug if high-risk-factor intervention (ie, cardiovascular or renal disease) existed. The primary end point of study was the mean change in primary end point from baseline to months 6-12 at which time the patient's heart failure was evaluated according to the Hamilton Disease Rating Scale II. Secondary end points were the pharmacy online store australia frequency of serious cardiovascular events (including new events, MI, or stroke) and mortality. Results: In all, 688 patients were randomized (mean [SD] age, 63 [11] years; median [IQR], 56 [14] 60 of these patients were women). In the placebo group, mean (SD) initial cholesterol level was 4.2 mmol/L (0.61 to 4.4 mmol/L); on average, patients underwent a mean (SD) of 11.6 months treatment, and in the drug group, mean (SD) initial cholesterol level was 4.4 mmol/L (0.39 to 4.8 mmol/L). At least one serious cardiovascular event (including MI, death, or hospitalization with a cardiovascular cause) occurred in 44/188 (22%) of the placebo-treated patients and in 20/194 (7%) of the drug-treated patients. In final analysis, mean (SD) cholesterol level change over 6 months was -0.6 (1.3; 2.2) mmol/L (P =.02), resulting in significant (P <.001) reduction in HDL cholesterol the drug group (0.2 mmol/L to 0.3 mmol/L; a 41% relative reduction). At 6 months, the overall mean (SD), per-protocol increase in HDL cholesterol the drug group was 0.0 (0.3; 0.2), whereas in the placebo group, there was an increase of 0.0 (0.9; 0.1). During the 8-month study, there were 60 serious cardiovascular events (including MI, death, or hospitalization with a cardiovascular cause) and 5 deaths, including 1 in the drug group. Among drug-treated patients, there were 5 patients with clinically significant cardiovascular events of the type identified with increased cardiovascular risk in 2-year prospective randomized studies [5,9,12]. Conclusion: In patients with a history of cardiovascular disease and non-high-risk risk medications, we found some benefit of simvastatin and niacin therapy. The reduction in cardiovascular events may be sustained.

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